ld50 of euphorbia hirta extract

ld50 of euphorbia hirta extract

Acute toxicity impacts of Euphorbia hirta L extract on ...

LD 50 of more than 5000 mg/kg of E. hirta methanol leaves extract is an indication that the extract is safe. However, lethal effect being found in this test indicated that the methanol crude extract of E. hirta had mild toxicity when given orally at 5g/kg body weight. Still the results of the current study agree with the wide use of this plant ...

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Antiulcer Effects of Methanol Extract of Euphorbia hirta ...

The soxhlet extraction of E. hirta gave a yield of 54.5 g of crude extract (5.45%). Phytochemical screening of E. hirta showed that the extract contains alkaloids, tannins, saponins, glycosides, flavonoids, and unsaturated steroids. Acute toxicity studies showed that LD

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Effects of Ethanolic Leaf Extract of Euphorbia hirta on ...

Twenty-four hour acute toxicity (LD 50) result of the ethanolic leaf extract of Euphorbia hirta. The different groups for the LD 50 of plant extract were given the different doses (ml) of extract above and the result presented in Table 1 Table 1: Result for the LD 50 experiment for plant extract. Dose (mg/kg) No of death Behavior

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Acute toxicity impacts of Euphorbia hirta L extract on ...

Background: The methanol extract of Euphorbia hirta L (Euphorbiaceae), which is used in traditional medicines, was tested for in vivo toxicity. Materials and methods: In vivo brine shrimp lethality assay and oral acute toxicity study at single high dose of 5000 mg/kg and observation for 14 days in mice were used to study the toxic effect of E. hirta.

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ANTIBACTERIAL ACTIVITIES AND TOXICOLOGICAL

Based on the LD50 studies doses of 60.4mg/kg body weight, 120.8mg/kg body weight, 241.5mg/kg body weight and 483.0mg/kg body weight were injected into each group of the rats through the intraperitoneal route ... concentrations of crude ethanolic extract of Euphorbia hirta) ) and .

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(PDF) Acute toxicity impacts of Euphorbia hirta L extract ...

The methanol extract of Euphorbia hirta L (Euphorbiaceae), which is used in traditional medicines, was tested for in vivo toxicity. In vivo brine shrimp lethality assay and oral acute toxicity ...

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EVALUATION OF ACUTE TOXICITY STUDY FOR EUPHORBIA

important aspects of Euphorbia hirta [6-9]. Extracts of E. hirta have been found to show anticancer activity. The aqueous extract of the herb strongly reduced the release of prostaglandins I2, E2, and, D 2. The aqueous extract also inhibits aflatoxin contamination in rice, wheat, maize, and mustard crops.

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Antiulcer Effects of Methanol Extract of Euphorbia hirta ...

The soxhlet extraction of E. hirta gave a yield of 54.5 g of crude extract (5.45%). Phytochemical screening of E. hirta showed that the extract contains alkaloids, tannins, saponins, glycosides, flavonoids, and unsaturated steroids. Acute toxicity studies showed that LD

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Antiulcer Effects of Methanol Extract of Euphorbia hirta ...

Therefore, LD 50 of the extract combined with honey was considered to be above 5000 mg/kg of the extract . This implies that the plant is a relative safe for consumption and is used in ethnomedicine, at doses not exceeding 5000 mg/kg of the extract. ... and S. P. Bako, “Toxicity effects of methanolic extract of Euphorbia hirta-honey mixture ...

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Antiulcer Effects of Methanol Extract of Euphorbia hirta ...

Phytochemical screening of E. hirta showed that the extract contains alkaloids, tannins, saponins, glycosides, flavonoids, and unsaturated steroids. Acute toxicity studies showed that LD 50 was greater than 5000mg/kg. The study showed that the crude extract of

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ANTIBACTERIAL ACTIVITIES AND TOXICOLOGICAL

Based on the LD50 studies doses of 60.4mg/kg body weight, 120.8mg/kg body weight, 241.5mg/kg body weight and 483.0mg/kg body weight were injected into each group of the rats through the intraperitoneal route ... concentrations of crude ethanolic extract of Euphorbia hirta) ) and .

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(PDF) Acute toxicity impacts of Euphorbia hirta L extract ...

The methanol extract of Euphorbia hirta L (Euphorbiaceae), which is used in traditional medicines, was tested for in vivo toxicity. In vivo brine shrimp lethality assay and oral acute toxicity ...

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EUPHORBIA HIRTA: Overview, Uses, Side Effects, Precautions ...

Euphorbia hirta is an herb. The parts of the plant that grow above the ground are used to make medicine. Euphorbia hirta is used for breathing disorders, dengue fever, digestive problems, severe ...

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A transmission electron microscopy study of the diversity ...

Euphorbia hirta (E. hirta) L. belongs to the family Euphorbiaceae. It is a small annual herb common to tropical countries. It is usually erect, slender-stemmed, spreading up to 80 cm tall, though sometimes it can be seen lying down. The plant is an annual broad-leaved herb that has a hairy stem with many branches from the base to the top.

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(PDF) Antibacterial activities and toxicological ...

Table 1: * Results of antibacterial screening of the different concentrations of crude ethanolic extract of Euphorbia hirta Concentrations Zones of inhibition (mm) of extract E. coli S. aureus P. aeruginosa B. subtilis Sa. typhi mg/ml a b a c 250 11.9 13.5 12.1 8.4 NI 200 9.8a 12.9b 11.3c 5.6d NI 150 8.0a 11.5b 8.2a NI NI 100 5.8a 10.6b 6.1a NI ...

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FR2639229A1 - Novel use of Euphorbia hirta L. in therapy ...

hirta euphorbia hirta euphorbia plant Prior art date 1988-11-18 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Granted Application number FR8815033A Other languages French (fr) Other versions ...

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Foods | Free Full-Text | Spray-Drying Microencapsulation ...

The present study was performed to spray-dry the high concentration of bioactive compounds from Euphorbia hirta L. extracts that have antidiabetic activity. The total phenolic content (TPC) and total flavonoid content (TFC) of four different extracts (crude extract, petroleum ether extract, chloroform extract and ethyl acetate extract) from the dried powder of Euphorbia hirta L. were ...

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Acute Toxicity of Cashew Nut Shell Extract (Anacardium ...

While, according to Hodgson and Levi (2000), LD 50 is a single dose that is able to cause the death of 50% of test animals. After obtaining this value, the safe dose range can be determined for further treatment. A research by Harlita (2004) showed that the LD 50 value on female golden snails (Pomacea canaliculata) and its eggs were 62.5 and 50 ppm, respectively.

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METHANOL EXTRACTION METHOD - Google Docs

Methanol, also known as methyl alcohol, wood alcohol, wood naphtha or wood spirits, is a chemical with formula C H 3 O H (often abbreviated MeOH). It is the simplest alcohol, and is a light, volatile, colorless, flammable, liquid with a distinctive odor that is very similar to but slightly sweeter than ethanol (drinking alcohol). At room temperature it is a polar liquid and is used as an ...

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Research Article

Euphorbia hirta Linn. (Euphorbiaceae) was selected for the present study considering its use in traditional medicine after thorough literature search to find out scientific basis of the claimed therapeutic potentials. E. hirta is an extensively studied plant by the scientific community.

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Antiulcer Effects of Methanol Extract of Euphorbia hirta ...

Unformatted text preview: Hindawi BioMed Research International Volume 2020, Article ID 6827504, 8 pages Research Article Antiulcer Effects of Methanol Extract of Euphorbia hirta and Honey Combination in Rats Ifeanyi P. Onyeka ,1 Sunday P. Bako,2 Mohammed M. Suleiman,3 Felix Afamefula Onyegbule,4 Ugonna C. Morikwe,5 and Cyril Onyeka Ogbue1 1 ...

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Protective effect of Euphorbia hirta and its components ...

May 13, 2015 · LD 50 was calculated by probit analysis. For venom neutralization studies, different concentrations of E. hirta extract was pre-incubated with twice the LD 50 of venom (w/w) for 1 h at 37 °C with a constant volume of 0.2 ml saline and injected intraperitonially (i.p) to mice (n=4 in a group).

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SCREENING OF EUPHORBIA HIRTA EXTRACTS FOR

in these extracts of Euphorbia hirta have revealed that the ethanolic extract contained the maximum phenolic content in terms of gallic acid equivalents, than aqueous extract. The total flavonoid content in aqueous and ethanol extracts were calculated as 27.37±0.39 QE mg/g and 41.32±1.69 QE mg/g. The flavonoid contents of ethanol

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Acute and Subchronic Toxicity Study of Euphorbia hirta L ...

Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats. BioMed Research International, 2013. Sreenivasan Sasidharan. Kwan Ping. Subramaniam Sreeramanan. Download PDF. Download Full PDF Package. This paper. A short summary of this paper. 37 Full PDFs related to this paper. Read Paper.

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The effects of Euphorbia hirta on the ultrastructure of ...

Sep 13, 2013 · Preparation of extract. Powdered Euphorbia hirta (30 g) was sequentially extracted with 300 ml of each n-hexane, chloroform, methanol and water. A total of 90 g powdered Euphorbia hirta was used in the preparation of the extract. The solvents in the extracts were removed via rotary evaporation under reduced pressure.

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et al. European Journal of Biomedical and Pharmaceutical ...

extract could be applied to the treatment of different diseases. Thus, Euphorbia hirta has great potential as a of bioactive extracts, which may lead to development of new drugs for clinical use. REFERENCES 1. Daphne SYL, Hui ME, Yu SC Mutagenic and antimutagenic activities of aqueous and methanol extracts of Euphorbia hirta.

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Antiplasmodial activities of ethanol extracts of Euphorbia ...

Nov 13, 2015 · extracts of the whole plant of Euphorbia hirta and the leaves of Vernonia amygdalina in Plasmodium berghei-infected mice. 2. Materials and methods 2.1. Plant materials Fresh whole plants of Euphorbia hirta and leaves of Vernonia amygdalina were collected from a notable organic farm in the premises of Water Works, Ede, Osun State,

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Registry - Research Details

Acute Oral Toxicity, Mutagenicity and Clastogenicity of the Crude Aqueous Extract of the Whole Plant of Euphorbia hirta L. (Family Euphorbiaceae) Project Description The decoction of the whole plant is used as a folkloric herbal treatment for Dengue Hemorrhagic Fever (DHF) in the country (Apostal et al 2009).

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Quercetin-3-O-rhamnoside from Euphorbia hirta protects ...

Jul 01, 2016 · The fractions of Euphorbia hirta methanolic extract were evaluated against Naja naja venom enzymes. • One of the active fractions inhibited multiple enzymes of Naja naja venom in vitro. • The active principle was identified as Quercetin-3-O-rhamnoside (QR). • Hemorrhage and edema causing activity of venom was also inhibited by QR ex vivo. •

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Acute oral toxicity. | Environmental Health Perspectives ...

Apr 01, 1998 · Sudam V, Potnuri A and Subhashini N (2017) Syk – GTP RAC-1 mediated immune-stimulatory effect of Cuscuta epithymum , Ipomoea batata and Euphorbia hirta plant extracts, Biomedicine & Pharmacotherapy, 10.1016/j.biopha.2017.10.060, 96, (742-749), Online publication date: 1

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Effectof Euphorbiahirta plantleaf ...

of Euphorbia hirta on the common carp (Cyprinus carpio) infected with Aeromonas hydrophila. Euphorbia hirta is a potential candidate and is widely used as a traditional medicinal herb in all the tropical countries. The previous studies reported that Euphorbia hirta extract has phenol, sugars, flavonoid, quercetine etc. as active ingredients ...

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Molecules | Free Full-Text | Evaluation of the Antioxidant ...

This study evaluated the chemical composition, antioxidant, anti-inflammatory and anticancer activities of a Euphorbia hirta L. extract. The antioxidant activities of whole E. hirta ethanol extract were determined by electron spin resonance spectrophotometric analysis of 1,1-diphenyl-2-picryl-hydrazyl (DPPH), hydroxyl, and alkyl radical levels and by using an online high-performance liquid ...

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Antimicrobial Properties of the Hydroethanolic Extract of ...

Objective : To evaluate the antimicrobial properties of hydroethanol extracts of Bauhinia rufescens L. and Euphorbia hirta L. Methodology and results : The hydroethanol extracts of Bauhinia rufescens L. and Euphorbia hirta L.; two plants of the Chadian traditional pharmacopoeia used in the treatment of infantile diarrhoea and gastroenteritis in adults were submitted to in vitro tests in order ...

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Adulticidal properties of synthesized silver nanoparticles ...

Aug 22, 2014 · AgNPs synthesized using Euphorbia hirta plant leaf extract against malarial vector A. stephensi were determined; the highest larval mortality was found in synthesized AgNPs against the first to fourth instar larvae and pupae with the following values: LC 50 10.14, 16.82, 21.51, and 27.89 ppm, respectively; LC 90 31.98, 50.38, 60.09, and 69.94 ...

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SciELO - Brasil - Efficacy of euphorbia hirta latex as ...

A. Preparation of extract: The latex of Euphorbia hirta was drained into glass tubes by cutting their stem apices. This latex was lyophilized at -40 0 C and the lyophilized powder was stored for further use. The dried powder was mixed with an appropriate volume of a

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